Ganoderma lucidum suppresses colon carcinogenesis and inflammation

Mushroom Ganoderma lucidum Prevents Colitis-Associated Carcinogenesis in Mice

BACKGROUND Epidemiological studies suggest that mushroom intake is inversely correlated with gastric, gastrointestinal and breast cancers. We have recently demonstrated anticancer and anti-inflammatory activity of triterpene extract isolated from mushroom Ganoderma lucidum (GLT). The aim of the present study was to evaluate whether GLT prevents colitis-associated carcinogenesis in mice. METHO...

Ganoderma lucidum

Infection, inflammation and colon carcinogenesis

Citation Wogan, G.N. et al. "Infection, inflammation and colon carcinogenesis. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters.

Ganoderma lucidum, Ganoderma neo-japonicum and Grifola frondosa towards rat

Ganodermanontriol, a lanostanoid triterpene from Ganoderma lucidum, suppresses growth of colon cancer cells through ß-catenin signaling.

Colorectal cancer is one of the most common cancers in men and women in the world. Previous molecular studies have revealed that deregulation of the ß-catenin signaling pathway plays a crucial role in the progression of colorectal cancer. Therefore, modulation of the ß-catenin pathway offers a strategy to control colorectal cancer progression. The medicinal mushroom Ganoderma lucidum (GL) is a ...